# CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia

> **NCT04375631** · PHASE1 · RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 120 (estimated)

## Conditions studied

- Recurrent Acute Myeloid Leukemia
- Recurrent Chronic Myelomonocytic Leukemia
- Recurrent Myelodysplastic Syndrome
- Refractory Acute Myeloid Leukemia
- Refractory Chronic Myelomonocytic Leukemia
- Refractory Mixed Phenotype Acute Leukemia
- Refractory Myelodysplastic Syndrome
- Refractory Acute Leukemia of Ambiguous Lineage
- Refractory Acute Undifferentiated Leukemia

## Interventions

- **DRUG:** Cladribine
- **DRUG:** Cyclophosphamide
- **DRUG:** Cyclosporine
- **DRUG:** Cytarabine
- **BIOLOGICAL:** Filgrastim
- **PROCEDURE:** Hematopoietic Cell Transplantation
- **DRUG:** Mitoxantrone
- **DRUG:** Mycophenolate Mofetil
- **DRUG:** Mycophenolate Sodium
- **RADIATION:** Total-Body Irradiation
- **DRUG:** Idarubicin
- **DRUG:** Fludarabine
- **DRUG:** Cytarabine
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** X-Ray Imaging
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT04375631
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-12-03
- **Primary completion:** 2027-02-28
- **Final completion:** 2027-03-17
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-03-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04375631

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04375631, "CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04375631. Licensed CC0.

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