Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis

NCT04384692 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

53

Enrollment

OTHER

Sponsor class

Conditions

Primary Myelofibrosis
Secondary Myelofibrosis

Interventions

PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
DRUG: Busulfan
DRUG: Cyclophosphamide
DRUG: Fludarabine
DRUG: Melphalan
DRUG: Methotrexate
DRUG: Mycophenolate Mofetil
DRUG: Ruxolitinib
DRUG: Tacrolimus
RADIATION: Total-Body Irradiation
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography
PROCEDURE: Bone Marrow Aspiration and Biopsy
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Ultrasound Imaging

Sponsor

Fred Hutchinson Cancer Center