# Combining Biomarkers (AFP, AFP-L3, and PIVKA-II) and Image Tools for Early Detection of Hepatocellular Carcinoma

> **NCT04414956** · NA · UNKNOWN · sponsor: **Korea University** · enrollment: 1418 (estimated)

## Conditions studied

- Liver Cirrhosis
- Hepatocellular Carcinoma
- Surveillance

## Interventions

- **DIAGNOSTIC_TEST:** AFP-L3
- **DIAGNOSTIC_TEST:** AFP
- **DIAGNOSTIC_TEST:** PIVKA-II
- **DIAGNOSTIC_TEST:** Sonography
- **DIAGNOSTIC_TEST:** CT

## Key facts

- **NCT ID:** NCT04414956
- **Lead sponsor:** Korea University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2016-07-01
- **Primary completion:** 2023-06-30
- **Final completion:** 2026-02-28
- **Target enrollment:** 1418 (ESTIMATED)
- **Last updated:** 2020-06-04

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04414956

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04414956, "Combining Biomarkers (AFP, AFP-L3, and PIVKA-II) and Image Tools for Early Detection of Hepatocellular Carcinoma". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT04414956. Licensed CC0.

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