# A Randomized Study of Smile Exercise for Dry Eye

> **NCT04421300** · NA · COMPLETED · sponsor: **Zhongshan Ophthalmic Center, Sun Yat-sen University** · enrollment: 299 (actual)

## Conditions studied

- Dry Eye
- Keratoconjunctivitis Sicca
- Eye Diseases
- Corneal Diseases
- Conjunctival Diseases

## Interventions

- **BEHAVIORAL:** smile exercise
- **DRUG:** 0.1% sodium hyaluronate eye drop

## Key facts

- **NCT ID:** NCT04421300
- **Lead sponsor:** Zhongshan Ophthalmic Center, Sun Yat-sen University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-07-02
- **Primary completion:** 2021-04-02
- **Final completion:** 2021-04-02
- **Target enrollment:** 299 (ACTUAL)
- **Last updated:** 2024-05-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04421300

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04421300, "A Randomized Study of Smile Exercise for Dry Eye". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT04421300. Licensed CC0.

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