# A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering

> **NCT04426669** · PHASE1,PHASE2 · COMPLETED · sponsor: **Intima Bioscience, Inc.** · enrollment: 23 (actual)

## Conditions studied

- Gastrointestinal Epithelial Cancer
- Gastrointestinal Neoplasms
- Cancer of Gastrointestinal Tract
- Cancer, Gastrointestinal
- Gastrointestinal Cancer
- Colo-rectal Cancer
- Pancreatic Cancer
- Gall Bladder Cancer
- Colon Cancer
- Esophageal Cancer
- Stomach Cancer

## Interventions

- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine
- **BIOLOGICAL:** Tumor-Infiltrating Lymphocytes (TIL)
- **DRUG:** Aldesleukin

## Key facts

- **NCT ID:** NCT04426669
- **Lead sponsor:** Intima Bioscience, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-05-15
- **Primary completion:** 2025-05-28
- **Final completion:** 2026-01-22
- **Target enrollment:** 23 (ACTUAL)
- **Last updated:** 2026-02-23

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04426669

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04426669, "A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04426669. Licensed CC0.

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