# Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid

> **NCT04426721** · PHASE3 · UNKNOWN · sponsor: **Humanitas Clinical and Research Center** · enrollment: 120 (estimated)

## Conditions studied

- Knee Osteoarthritis

## Interventions

- **DRUG:** Ozone
- **DRUG:** Hyaluronic Acid

## Key facts

- **NCT ID:** NCT04426721
- **Lead sponsor:** Humanitas Clinical and Research Center
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2020-06
- **Primary completion:** 2021-12
- **Final completion:** 2022-12
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2020-06-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04426721

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04426721, "Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04426721. Licensed CC0.

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