# A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects

> **NCT04443192** · PHASE1 · TERMINATED · sponsor: **Z Factor Limited** · enrollment: 69 (actual)

## Conditions studied

- Alpha1 Anti-Trypsin Deficiency

## Interventions

- **DRUG:** ZF874
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT04443192
- **Lead sponsor:** Z Factor Limited
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2020-08-03
- **Primary completion:** 2022-09-12
- **Final completion:** 2022-09-12
- **Target enrollment:** 69 (ACTUAL)
- **Why stopped:** Based on the results observed to date, the Sponsor concluded that ZF874 was unlikely to achieve the desired target product profile.
- **Last updated:** 2022-09-19

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04443192

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04443192, "A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT04443192. Licensed CC0.

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