# Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression

> **NCT04448327** · NA · COMPLETED · sponsor: **Massachusetts General Hospital** · enrollment: 62 (actual)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DEVICE:** active tVNS
- **DEVICE:** Sham tVNS

## Key facts

- **NCT ID:** NCT04448327
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-01-29
- **Primary completion:** 2025-06-13
- **Final completion:** 2025-06-14
- **Target enrollment:** 62 (ACTUAL)
- **Last updated:** 2026-04-29

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04448327

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04448327, "Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression". Retrieved via AI Analytics 2026-05-31 from https://api.ai-analytics.org/clinical/NCT04448327. Licensed CC0.

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