# A Study to Compare Efficacy and Safety of Trifarotene Cream When Used With an Oral Antibiotic for the Treatment of Severe Acne Vulgaris (AV)

> **NCT04451330** · PHASE4 · COMPLETED · sponsor: **Galderma R&D** · enrollment: 202 (actual)

## Conditions studied

- Acne Vulgaris

## Interventions

- **DRUG:** Trifarotene cream
- **DRUG:** Doxycycline hyclate
- **DRUG:** Trifarotene Vehicle
- **DRUG:** Doxycycline Placebo

## Key facts

- **NCT ID:** NCT04451330
- **Lead sponsor:** Galderma R&D
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-07-29
- **Primary completion:** 2021-04-26
- **Final completion:** 2021-04-26
- **Target enrollment:** 202 (ACTUAL)
- **Last updated:** 2022-05-10


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04451330

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04451330, "A Study to Compare Efficacy and Safety of Trifarotene Cream When Used With an Oral Antibiotic for the Treatment of Severe Acne Vulgaris (AV)". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT04451330. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*