# Association Between Methotrexate Erythrocyte Polyglutamate Concentration and Biological Drug Concentration and Clinical Response in Rheumatoid Arthritis Patients Treated With Subcutaneous Injectable Methotrexate and a First Biological Drug

> **NCT04470453** · PHASE4 · TERMINATED · sponsor: **Centre Hospitalier Universitaire de Saint Etienne** · enrollment: 16 (actual)

## Conditions studied

- Rheumatoid Arthritis

## Interventions

- **BIOLOGICAL:** Blood sample
- **DIAGNOSTIC_TEST:** CRQ

## Key facts

- **NCT ID:** NCT04470453
- **Lead sponsor:** Centre Hospitalier Universitaire de Saint Etienne
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2020-10-08
- **Primary completion:** 2024-04-04
- **Final completion:** 2024-04-04
- **Target enrollment:** 16 (ACTUAL)
- **Why stopped:** Inclusion rate too low to meet the evaluation criterion.
- **Last updated:** 2025-01-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04470453

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04470453, "Association Between Methotrexate Erythrocyte Polyglutamate Concentration and Biological Drug Concentration and Clinical Response in Rheumatoid Arthritis Patients Treated With Subcutaneous Injectable Methotrexate and a First Biological Drug". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT04470453. Licensed CC0.

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