# TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY

> **NCT04481256** · NA · RECRUITING · sponsor: **Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)** · enrollment: 49 (estimated)

## Conditions studied

- Carcinoma, Squamous Cell
- Oesophageal Cancer

## Interventions

- **RADIATION:** External beam radiotherapy
- **DRUG:** Bintrafusp alfa
- **DRUG:** Paclitaxel
- **DRUG:** Carboplatin

## Key facts

- **NCT ID:** NCT04481256
- **Lead sponsor:** Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-11-11
- **Primary completion:** 2025-09-01
- **Final completion:** 2030-09-01
- **Target enrollment:** 49 (ESTIMATED)
- **Last updated:** 2024-07-26

## Collaborators

- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04481256

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04481256, "TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04481256. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*