B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

NCT04483778 · clinicaltrials.gov ↗

PHASE1

Phase

ACTIVE_NOT_RECRUITING

Status

68

Enrollment

OTHER

Sponsor class

Conditions

Pediatric Solid Tumor
Germ Cell Tumor
Retinoblastoma
Hepatoblastoma
Wilms Tumor
Rhabdoid Tumor
Carcinoma
Osteosarcoma
Ewing Sarcoma
Rhabdomyosarcoma
Synovial Sarcoma
Clear Cell Sarcoma
Malignant Peripheral Nerve Sheath Tumors
Desmoplastic Small Round Cell Tumor
Soft Tissue Sarcoma
Neuroblastoma
Melanoma

Interventions

BIOLOGICAL: second generation 4-1BBζ B7H3-EGFRt-DHFR
BIOLOGICAL: second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG
DRUG: Pembrolizumab

Sponsor

Seattle Children's Hospital