# Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

> **NCT04489719** · — · RECRUITING · sponsor: **University of Washington** · enrollment: 48 (estimated)

## Conditions studied

- Castration-Resistant Prostate Carcinoma
- Metastatic Malignant Neoplasm in the Bone
- Metastatic Prostate Carcinoma
- Stage IVB Prostate Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **OTHER:** Questionnaire Administration
- **DRUG:** Radium Ra 223 Dichloride

## Key facts

- **NCT ID:** NCT04489719
- **Lead sponsor:** University of Washington
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2021-04-16
- **Primary completion:** 2026-08-01
- **Final completion:** 2029-08-01
- **Target enrollment:** 48 (ESTIMATED)
- **Last updated:** 2026-02-17

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04489719

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04489719, "Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT04489719. Licensed CC0.

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