# Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D (RHYTHM)

> **NCT04491136** · PHASE4 · TERMINATED · sponsor: **Novartis Pharmaceuticals** · enrollment: 201 (actual)

## Conditions studied

- Heart Failure

## Interventions

- **DRUG:** ACEI/ARB
- **DRUG:** ARNI

## Key facts

- **NCT ID:** NCT04491136
- **Lead sponsor:** Novartis Pharmaceuticals
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2020-11-11
- **Primary completion:** 2023-06-08
- **Final completion:** 2023-06-08
- **Target enrollment:** 201 (ACTUAL)
- **Why stopped:** Company decision
- **Last updated:** 2025-05-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04491136

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04491136, "Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D (RHYTHM)". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04491136. Licensed CC0.

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