# A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

> **NCT04513912** · PHASE3 · COMPLETED · sponsor: **Janssen Research & Development, LLC** · enrollment: 757 (actual)

## Conditions studied

- Depressive Disorder, Major

## Interventions

- **DRUG:** Seltorexant
- **DRUG:** Matching placebo to Seltorexant
- **DRUG:** Quetiapine XR
- **DRUG:** Matching placebo to Quetiapine XR

## Key facts

- **NCT ID:** NCT04513912
- **Lead sponsor:** Janssen Research & Development, LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-09-15
- **Primary completion:** 2023-10-03
- **Final completion:** 2023-10-03
- **Target enrollment:** 757 (ACTUAL)
- **Last updated:** 2025-08-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04513912

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04513912, "A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT04513912. Licensed CC0.

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