# Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

> **NCT04514497** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 28 (actual)

## Conditions studied

- Metastatic Lung Small Cell Carcinoma
- Metastatic Malignant Solid Neoplasm
- Metastatic Neuroendocrine Carcinoma
- Metastatic Pancreatic Adenocarcinoma
- Stage III Lung Cancer AJCC v8
- Stage III Pancreatic Cancer AJCC v8
- Stage IV Lung Cancer AJCC v8
- Stage IV Pancreatic Cancer AJCC v8
- Unresectable Lung Small Cell Carcinoma
- Unresectable Malignant Solid Neoplasm
- Unresectable Neuroendocrine Carcinoma
- Unresectable Pancreatic Adenocarcinoma

## Interventions

- **PROCEDURE:** Biopsy
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Elimusertib
- **DRUG:** Irinotecan Hydrochloride
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Topotecan Hydrochloride

## Key facts

- **NCT ID:** NCT04514497
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-10-20
- **Primary completion:** 2025-02-15
- **Final completion:** 2026-03-04
- **Target enrollment:** 28 (ACTUAL)
- **Last updated:** 2025-03-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04514497

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04514497, "Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT04514497. Licensed CC0.

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