# Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

> **NCT04518462** · PHASE3 · COMPLETED · sponsor: **Pacira Pharmaceuticals, Inc** · enrollment: 121 (actual)

## Conditions studied

- Lower Extremity Surgery
- Bunion
- Metatarsophalangeal Fushion
- Midfoot Fusion
- Hindfoot Fushion
- Total Ankle Arthroplasty

## Interventions

- **DRUG:** Exparel
- **DRUG:** Bupivacaine Hydrochloride

## Key facts

- **NCT ID:** NCT04518462
- **Lead sponsor:** Pacira Pharmaceuticals, Inc
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-10-20
- **Primary completion:** 2021-04-05
- **Final completion:** 2021-04-05
- **Target enrollment:** 121 (ACTUAL)
- **Last updated:** 2022-07-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04518462

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04518462, "Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT04518462. Licensed CC0.

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