# Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

> **NCT04528680** · PHASE1,PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Northwestern University** · enrollment: 57 (estimated)

## Conditions studied

- Glioblastoma
- Gliosarcoma
- GBM
- Glioblastoma Multiforme
- Glioblastoma, IDH-wildtype
- Recurrent Glioblastoma

## Interventions

- **DEVICE:** Sonication for opening of blood-brain barrier
- **DRUG:** Chemotherapy, albumin-bound paclitaxel
- **DRUG:** Chemotherapy, carboplatin

## Key facts

- **NCT ID:** NCT04528680
- **Lead sponsor:** Northwestern University
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-10-29
- **Primary completion:** 2026-12-31
- **Final completion:** 2026-12-31
- **Target enrollment:** 57 (ESTIMATED)
- **Last updated:** 2026-04-13

## Collaborators

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- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04528680

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04528680, "Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT04528680. Licensed CC0.

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