Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

NCT04530487 · clinicaltrials.gov ↗

PHASE2

Phase

TERMINATED

Status

1

Enrollment

OTHER

Sponsor class

Stopped PI Request

Conditions

Desmoplastic Small Round Cell Tumor
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Recurrent Desmoplastic Small Round Cell Tumor
Recurrent Malignant Peripheral Nerve Sheath Tumor
Recurrent Malignant Solid Neoplasm
Recurrent Neuroblastoma
Recurrent Rhabdomyosarcoma
Refractory Desmoplastic Small Round Cell Tumor
Refractory Malignant Peripheral Nerve Sheath Tumor
Refractory Malignant Solid Neoplasm
Refractory Neuroblastoma
Refractory Rhabdomyosarcoma

Interventions

PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
DRUG: Cyclosporine
DRUG: Etoposide
DRUG: Fludarabine Phosphate
BIOLOGICAL: Lapine T-Lymphocyte Immune Globulin
DRUG: Melphalan
DRUG: Mycophenolate Mofetil
DRUG: Tacrolimus
DRUG: Thiotepa

Sponsor

M.D. Anderson Cancer Center