# A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

> **NCT04532749** · PHASE3 · TERMINATED · sponsor: **Janssen Research & Development, LLC** · enrollment: 212 (actual)

## Conditions studied

- Depressive Disorder, Major

## Interventions

- **DRUG:** Seltorexant
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT04532749
- **Lead sponsor:** Janssen Research & Development, LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2020-09-15
- **Primary completion:** 2022-05-24
- **Final completion:** 2022-07-14
- **Target enrollment:** 212 (ACTUAL)
- **Why stopped:** 42847922MDD3002 was stopped based on the interim analysis (IA) results as recommended by the Independent Data Monitoring Committee (IDMC)
- **Last updated:** 2025-06-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04532749

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04532749, "A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT04532749. Licensed CC0.

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