# Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

> **NCT04539964** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **SetPoint Medical Corporation** · enrollment: 243 (actual)

## Conditions studied

- Rheumatoid Arthritis

## Interventions

- **PROCEDURE:** Implant Procedure
- **DRUG:** Conventional Synthetic DMARD
- **DEVICE:** Active stimulation
- **DEVICE:** Non-active stimulation

## Key facts

- **NCT ID:** NCT04539964
- **Lead sponsor:** SetPoint Medical Corporation
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-01-11
- **Primary completion:** 2024-05-16
- **Final completion:** 2027-10
- **Target enrollment:** 243 (ACTUAL)
- **Last updated:** 2026-04-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04539964

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04539964, "Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04539964. Licensed CC0.

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