# Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

> **NCT04541654** · — · RECRUITING · sponsor: **Dana-Farber Cancer Institute** · enrollment: 1500 (estimated)

## Conditions studied

- Li-Fraumeni Syndrome
- TP53 Gene Mutation
- Hereditary Cancer Syndrome
- Clonal Hematopoiesis
- Mosaicism

## Interventions

- **GENETIC:** Data and Specimen Collection

## Key facts

- **NCT ID:** NCT04541654
- **Lead sponsor:** Dana-Farber Cancer Institute
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2020-09-15
- **Primary completion:** 2030-12-31
- **Final completion:** 2032-12-31
- **Target enrollment:** 1500 (ESTIMATED)
- **Last updated:** 2026-03-27

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04541654

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04541654, "Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04541654. Licensed CC0.

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