# A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

> **NCT04544436** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Hoffmann-La Roche** · enrollment: 864 (actual)

## Conditions studied

- Multiple Sclerosis

## Interventions

- **DRUG:** Ocrelizumab
- **DRUG:** Ocrelizumab
- **DRUG:** Antihistamine
- **DRUG:** Methylprednisolone

## Key facts

- **NCT ID:** NCT04544436
- **Lead sponsor:** Hoffmann-La Roche
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-11-26
- **Primary completion:** 2024-12-19
- **Final completion:** 2028-08-31
- **Target enrollment:** 864 (ACTUAL)
- **Last updated:** 2026-05-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04544436

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04544436, "A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04544436. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*