A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

NCT04546399 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

461

Enrollment

NIH

Sponsor class

Conditions

Down Syndrome
Recurrent B Acute Lymphoblastic Leukemia

Interventions

RADIATION: 3-Dimensional Conformal Radiation Therapy
PROCEDURE: Biospecimen Collection
BIOLOGICAL: Blinatumomab
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
DRUG: Calaspargase Pegol
DRUG: Cytarabine
DRUG: Dexamethasone
DRUG: Hydrocortisone Sodium Succinate
PROCEDURE: Lumbar Puncture
DRUG: Mercaptopurine
DRUG: Methotrexate
BIOLOGICAL: Nivolumab
DRUG: Pegaspargase
DRUG: Pegcrisantaspase
DRUG: Vincristine Sulfate

Sponsor

National Cancer Institute (NCI)