# A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.

> **NCT04562597** · PHASE1,PHASE2 · COMPLETED · sponsor: **Medical University of South Carolina** · enrollment: 50 (actual)

## Conditions studied

- Surgery

## Interventions

- **DRUG:** Dose Response Curve Placebo
- **DRUG:** Dose Response Curve N-acetylcysteine 50 mg/kg
- **DRUG:** Dose Response Curve N-acetylcysteine 100 mg/kg
- **DRUG:** Dose Response Curve N-acetylcysteine 150 mg/kg
- **DRUG:** Opioid Reduction with Optimal N-acetylcysteine Dose
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT04562597
- **Lead sponsor:** Medical University of South Carolina
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-01-20
- **Primary completion:** 2022-05-20
- **Final completion:** 2022-05-21
- **Target enrollment:** 50 (ACTUAL)
- **Last updated:** 2023-02-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04562597

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04562597, "A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04562597. Licensed CC0.

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