# A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

> **NCT04573140** · PHASE1 · RECRUITING · sponsor: **University of Florida** · enrollment: 28 (estimated)

## Conditions studied

- Adult Glioblastoma
- High Grade Glioma
- WHO Grade III or IV Malignant Glioma

## Interventions

- **BIOLOGICAL:** Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs)

## Key facts

- **NCT ID:** NCT04573140
- **Lead sponsor:** University of Florida
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-12-13
- **Primary completion:** 2027-07-01
- **Final completion:** 2029-07-01
- **Target enrollment:** 28 (ESTIMATED)
- **Last updated:** 2026-04-24

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04573140

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04573140, "A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT04573140. Licensed CC0.

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