# Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

> **NCT04576104** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Northwestern University** · enrollment: 51 (actual)

## Conditions studied

- Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia
- Endometrial Carcinoma

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **DRUG:** Extended Release Metformin Hydrochloride
- **DRUG:** Megestrol Acetate
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT04576104
- **Lead sponsor:** Northwestern University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-11-29
- **Primary completion:** 2025-08-28
- **Final completion:** 2026-06-30
- **Target enrollment:** 51 (ACTUAL)
- **Last updated:** 2026-01-21

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04576104

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04576104, "Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT04576104. Licensed CC0.

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