# Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome

> **NCT04580355** · PHASE4 · UNKNOWN · sponsor: **University of Campinas, Brazil** · enrollment: 30 (estimated)

## Conditions studied

- Microbial Colonization
- Periodontal Diseases
- Periodontal Inflammation

## Interventions

- **PROCEDURE:** One-Stage Full Mouth Debridement
- **DRUG:** Amoxicillin 500mg
- **DRUG:** Metronidazole 400mg
- **DRUG:** Amoxicillin Placebo
- **DRUG:** Metronidazole Placebo

## Key facts

- **NCT ID:** NCT04580355
- **Lead sponsor:** University of Campinas, Brazil
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2021-07
- **Primary completion:** 2022-07
- **Final completion:** 2022-10
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2021-05-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04580355

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04580355, "Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04580355. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*