# Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne

> **NCT04582383** · PHASE4 · ACTIVE_NOT_RECRUITING · sponsor: **University of Pennsylvania** · enrollment: 350 (estimated)

## Conditions studied

- Acne

## Interventions

- **DRUG:** Spironolactone
- **DRUG:** Doxycycline Hyclate

## Key facts

- **NCT ID:** NCT04582383
- **Lead sponsor:** University of Pennsylvania
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-03-30
- **Primary completion:** 2026-02-13
- **Final completion:** 2026-07-31
- **Target enrollment:** 350 (ESTIMATED)
- **Last updated:** 2026-03-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04582383

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04582383, "Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT04582383. Licensed CC0.

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