# A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients

> **NCT04584125** · NA · NOT_YET_RECRUITING · sponsor: **Joseph B. Ciolino, MD** · enrollment: 216 (estimated)

## Conditions studied

- Keratoconus

## Interventions

- **DRUG:** Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light
- **DRUG:** Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light

## Key facts

- **NCT ID:** NCT04584125
- **Lead sponsor:** Joseph B. Ciolino, MD
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2027-01-01
- **Primary completion:** 2028-05-01
- **Final completion:** 2028-11-30
- **Target enrollment:** 216 (ESTIMATED)
- **Last updated:** 2026-04-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04584125

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04584125, "A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04584125. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*