# Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

> **NCT04588246** · PHASE3 · TERMINATED · sponsor: **NRG Oncology** · enrollment: 19 (actual)

## Conditions studied

- Anatomic Stage IV Breast Cancer AJCC v8
- Metastatic Lung Non-Small Cell Carcinoma
- Metastatic Lung Small Cell Carcinoma
- Metastatic Malignant Breast Neoplasm
- Metastatic Malignant Digestive System Neoplasm
- Metastatic Malignant Neoplasm in the Brain
- Metastatic Malignant Solid Neoplasm
- Metastatic Melanoma
- Metastatic Renal Cell Carcinoma
- Recurrent Brain Neoplasm
- Stage IV Lung Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Memantine
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration
- **RADIATION:** Stereotactic Radiosurgery
- **RADIATION:** Whole-Brain Radiotherapy

## Key facts

- **NCT ID:** NCT04588246
- **Lead sponsor:** NRG Oncology
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2021-08-05
- **Primary completion:** 2024-08-06
- **Final completion:** 2024-08-06
- **Target enrollment:** 19 (ACTUAL)
- **Why stopped:** Inadequate accrual rate
- **Last updated:** 2025-06-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04588246

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04588246, "Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT04588246. Licensed CC0.

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