# Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?

> **NCT04589546** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Centre Hospitalier Universitaire, Amiens** · enrollment: 310 (estimated)

## Conditions studied

- Acute Kidney Injury
- Septic Shock
- Nicotinamide
- Mortality

## Interventions

- **DRUG:** Nicotinamide treatment
- **DRUG:** placebo treatment

## Key facts

- **NCT ID:** NCT04589546
- **Lead sponsor:** Centre Hospitalier Universitaire, Amiens
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-10-01
- **Primary completion:** 2025-09
- **Final completion:** 2025-09
- **Target enrollment:** 310 (ESTIMATED)
- **Last updated:** 2025-08-24

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04589546

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04589546, "Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT04589546. Licensed CC0.

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