# Metabolism Informed Smoking Treatment: The MIST RCT

> **NCT04590404** · PHASE3 · COMPLETED · sponsor: **Vanderbilt-Ingram Cancer Center** · enrollment: 606 (actual)

## Conditions studied

- Smoking

## Interventions

- **BEHAVIORAL:** Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach.
- **DRUG:** Nicotine Replacement Therapy
- **DRUG:** Varenicline
- **OTHER:** Metabolism Informed Smoking Treatment (Nicotine metabolite ratio (NMR)-based selection of pharmacotherapy)

## Key facts

- **NCT ID:** NCT04590404
- **Lead sponsor:** Vanderbilt-Ingram Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-11-17
- **Primary completion:** 2024-05-20
- **Final completion:** 2024-11-22
- **Target enrollment:** 606 (ACTUAL)
- **Last updated:** 2025-12-05

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04590404

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04590404, "Metabolism Informed Smoking Treatment: The MIST RCT". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT04590404. Licensed CC0.

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