# Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients

> **NCT04606186** · NA · UNKNOWN · sponsor: **University of Erlangen-Nürnberg** · enrollment: 34 (estimated)

## Conditions studied

- Gingivitis
- Periodontal Inflammation
- Orthodontic Appliance Complication

## Interventions

- **DIETARY_SUPPLEMENT:** Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- **DIETARY_SUPPLEMENT:** Placebo-lozenges (BioGaia)

## Key facts

- **NCT ID:** NCT04606186
- **Lead sponsor:** University of Erlangen-Nürnberg
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2020-10-19
- **Primary completion:** 2023-11-01
- **Final completion:** 2023-11-01
- **Target enrollment:** 34 (ESTIMATED)
- **Last updated:** 2022-05-18

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04606186

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04606186, "Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT04606186. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*