# Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes

> **NCT04614168** · NA · COMPLETED · sponsor: **University of Edinburgh** · enrollment: 24 (actual)

## Conditions studied

- Type 1 Diabetes
- Type 1 Diabetes Mellitus With Hypoglycemia
- Hypoglycemia
- Hypoglycemia Unawareness
- Glucagon Deficiency
- Insulin Hypoglycemia

## Interventions

- **PROCEDURE:** Stepped hyperinsulinaemic-hypoglycaemic clamp study
- **DEVICE:** Insulin pump
- **DEVICE:** Continuous glucose monitor
- **OTHER:** Low carbohydrate diet
- **DEVICE:** Blinded continuous glucose monitor
- **PROCEDURE:** Stable isotope studies- D2 Glucose and D5 Glycerol

## Key facts

- **NCT ID:** NCT04614168
- **Lead sponsor:** University of Edinburgh
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-07-26
- **Primary completion:** 2023-09-22
- **Final completion:** 2025-12-26
- **Target enrollment:** 24 (ACTUAL)
- **Last updated:** 2026-01-28

## Collaborators

- NHS Lothian
- The Leona M. and Harry B. Helmsley Charitable Trust
- Tandem Diabetes Care, Inc.
- DexCom, Inc.

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04614168

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04614168, "Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes". Retrieved via AI Analytics 2026-07-31 from https://api.ai-analytics.org/clinical/NCT04614168. Licensed CC0.

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