# Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

> **NCT04620382** · EARLY_PHASE1 · COMPLETED · sponsor: **Vanderbilt University Medical Center** · enrollment: 31 (actual)

## Conditions studied

- Neurogenic Orthostatic Hypotension
- Autonomic Failure
- Pure Autonomic Failure
- Multiple System Atrophy
- Parkinson Disease

## Interventions

- **DRUG:** Midodrine
- **DRUG:** Placebo pill
- **DEVICE:** Abdominal compression
- **DEVICE:** sham compression

## Key facts

- **NCT ID:** NCT04620382
- **Lead sponsor:** Vanderbilt University Medical Center
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-11-09
- **Primary completion:** 2025-07-01
- **Final completion:** 2025-12-01
- **Target enrollment:** 31 (ACTUAL)
- **Last updated:** 2026-05-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04620382

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04620382, "Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT04620382. Licensed CC0.

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