# The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

> **NCT04650841** · EARLY_PHASE1 · NOT_YET_RECRUITING · sponsor: **Trustees of Dartmouth College** · enrollment: 60 (estimated)

## Conditions studied

- Pain
- Rejection
- Placebo Effect

## Interventions

- **DRUG:** Placebo Cream with Naloxone
- **DRUG:** Control Cream with Naloxone
- **DRUG:** Placebo Cream with Saline
- **DRUG:** Control Cream with Saline

## Key facts

- **NCT ID:** NCT04650841
- **Lead sponsor:** Trustees of Dartmouth College
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-09-01
- **Primary completion:** 2027-03-01
- **Final completion:** 2027-03-01
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2025-12-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04650841

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04650841, "The Role of the Opioid System in Placebo Effects on Pain and Social Rejection". Retrieved via AI Analytics 2026-07-22 from https://api.ai-analytics.org/clinical/NCT04650841. Licensed CC0.

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