# A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

> **NCT04655404** · EARLY_PHASE1 · RECRUITING · sponsor: **Nationwide Children's Hospital** · enrollment: 15 (estimated)

## Conditions studied

- High Grade Glioma
- Diffuse Intrinsic Pontine Glioma

## Interventions

- **DRUG:** Larotrectinib
- **PROCEDURE:** Larotrectinib surgical

## Key facts

- **NCT ID:** NCT04655404
- **Lead sponsor:** Nationwide Children's Hospital
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-04-08
- **Primary completion:** 2026-12-01
- **Final completion:** 2036-12-01
- **Target enrollment:** 15 (ESTIMATED)
- **Last updated:** 2026-03-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04655404

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04655404, "A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04655404. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*