Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).

Conditions

• Eye Diseases
• Macular Degeneration, Wet
• Sub-Macular Hemorrhage

Interventions

• PROCEDURE: Pars plana vitrectomy
• DRUG: Intravitreal 2 mg aflibercept will be injected at baseline then monthly for two further doses, then 2-monthly until month 12
• DRUG: subretinal injection of recombinant TPA (Alteplase) up to a maximum of 25 micrograms in 0.2 mls
• DRUG: Intravitreal 20% sulfahexafluoride (SF6) gas tamponade

Sponsor

King's College Hospital NHS Trust

Collaborators

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