# Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx

> **NCT04667585** · NA · RECRUITING · sponsor: **Duke University** · enrollment: 120 (estimated)

## Conditions studied

- Oropharynx Cancer

## Interventions

- **RADIATION:** De-escalated radiation dose
- **RADIATION:** Standard radiation dose
- **OTHER:** 18 fluorodeoxyglucose (FDG)-positron emission tomography (PET)-Computed Tomography (CT)

## Key facts

- **NCT ID:** NCT04667585
- **Lead sponsor:** Duke University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-04-12
- **Primary completion:** 2028-01
- **Final completion:** 2028-01
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-02-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04667585

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04667585, "Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT04667585. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*