# Comparison of HBV Reactivation Between Patients With High HBV-DNA and Low HBV-DNA Loads Undergoing ICI and Concurrent Antiviral Prophylaxis: a Prospective Observational Study

> **NCT04680598** · — · UNKNOWN · sponsor: **Sun Yat-sen University** · enrollment: 800 (estimated)

## Conditions studied

- Hepatocellular Carcinoma

## Interventions

- **DRUG:** ICI
- **DRUG:** Antiviral Prophylaxis

## Key facts

- **NCT ID:** NCT04680598
- **Lead sponsor:** Sun Yat-sen University
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** UNKNOWN
- **Start date:** 2020-12-25
- **Primary completion:** 2023-12-31
- **Final completion:** 2023-12-31
- **Target enrollment:** 800 (ESTIMATED)
- **Last updated:** 2023-08-02

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04680598

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04680598, "Comparison of HBV Reactivation Between Patients With High HBV-DNA and Low HBV-DNA Loads Undergoing ICI and Concurrent Antiviral Prophylaxis: a Prospective Observational Study". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04680598. Licensed CC0.

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