# Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

> **NCT04693377** · NA · RECRUITING · sponsor: **M.D. Anderson Cancer Center** · enrollment: 40 (estimated)

## Conditions studied

- Castration-Resistant Prostate Carcinoma
- Metastatic Colorectal Carcinoma
- Metastatic Malignant Neoplasm in the Bone
- Metastatic Malignant Solid Neoplasm
- Metastatic Melanoma
- Metastatic Prostate Carcinoma
- Metastatic Renal Cell Carcinoma
- Metastatic Sarcoma
- Metastatic Thyroid Gland Carcinoma
- Metastatic Urothelial Carcinoma
- Stage IV Colorectal Cancer AJCC v8
- Stage IV Prostate Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8
- Stage IVA Colorectal Cancer AJCC v8
- Stage IVA Prostate Cancer AJCC v8
- Stage IVB Colorectal Cancer AJCC v8
- Stage IVB Prostate Cancer AJCC v8
- Stage IVC Colorectal Cancer AJCC v8

## Interventions

- **PROCEDURE:** Cryosurgery
- **OTHER:** Quality-of-Life Assessment
- **RADIATION:** Stereotactic Body Radiation Therapy

## Key facts

- **NCT ID:** NCT04693377
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-03-16
- **Primary completion:** 2027-04-01
- **Final completion:** 2027-04-01
- **Target enrollment:** 40 (ESTIMATED)
- **Last updated:** 2026-04-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04693377

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04693377, "Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04693377. Licensed CC0.

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