# Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

> **NCT04703101** · PHASE1 · RECRUITING · sponsor: **Jonsson Comprehensive Cancer Center** · enrollment: 25 (estimated)

## Conditions studied

- Locally Advanced Rectal Carcinoma
- Rectal Adenocarcinoma
- Stage II Rectal Cancer AJCC v8
- Stage IIA Rectal Cancer AJCC v8
- Stage IIB Rectal Cancer AJCC v8
- Stage IIC Rectal Cancer AJCC v8
- Stage III Rectal Cancer AJCC v8
- Stage IIIA Rectal Cancer AJCC v8
- Stage IIIB Rectal Cancer AJCC v8
- Stage IIIC Rectal Cancer AJCC v8

## Interventions

- **DRUG:** Capecitabine
- **DRUG:** Fluorouracil
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **DRUG:** Leucovorin
- **DRUG:** Oxaliplatin
- **OTHER:** Quality-of-Life Assessment
- **BEHAVIORAL:** Surveillance
- **PROCEDURE:** Total Mesorectal Excision

## Key facts

- **NCT ID:** NCT04703101
- **Lead sponsor:** Jonsson Comprehensive Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-02-11
- **Primary completion:** 2026-10-01
- **Final completion:** 2027-10-15
- **Target enrollment:** 25 (ESTIMATED)
- **Last updated:** 2026-03-30

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04703101

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04703101, "Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04703101. Licensed CC0.

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