# Modulate-CF: Cystic Fibrosis Transmembrane Regulator (CFTR) Biomarker Study to Evaluate the Rescue of Mutant CFTR in Patients With Cystic Fibrosis Treated With CFTR-modulators

> **NCT04732910** · — · RECRUITING · sponsor: **Charite University, Berlin, Germany** · enrollment: 500 (estimated)

## Conditions studied

- Cystic Fibrosis

## Interventions

- **DRUG:** Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor, Vanzacaftor-Tezacaftor-Deutivacaftor

## Key facts

- **NCT ID:** NCT04732910
- **Lead sponsor:** Charite University, Berlin, Germany
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2018-07-01
- **Primary completion:** 2027-03-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 500 (ESTIMATED)
- **Last updated:** 2026-02-24

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04732910

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04732910, "Modulate-CF: Cystic Fibrosis Transmembrane Regulator (CFTR) Biomarker Study to Evaluate the Rescue of Mutant CFTR in Patients With Cystic Fibrosis Treated With CFTR-modulators". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT04732910. Licensed CC0.

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