# A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease

> **NCT04734197** · PHASE2 · COMPLETED · sponsor: **Surface Ophthalmics, Inc.** · enrollment: 349 (actual)

## Conditions studied

- Dry Eye Disease

## Interventions

- **DRUG:** SURF-100 (Combination of 0.3% Mycophenolic Acid and 0.01% Betamethasone Sodium Phosphate)
- **DRUG:** Mycophenolic Acid 0.1%
- **DRUG:** Mycophenolic Acid 0.3%
- **DRUG:** Betamethasone Sodium Phosphate 0.01%
- **DRUG:** Placebo Comparator: Vehicle
- **DRUG:** Cyclosporine 0.05% Ophthalmic Emulsion
- **DRUG:** Lifitegrast 5% Ophthalmic Solution

## Key facts

- **NCT ID:** NCT04734197
- **Lead sponsor:** Surface Ophthalmics, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-01-11
- **Primary completion:** 2022-03-25
- **Final completion:** 2022-03-25
- **Target enrollment:** 349 (ACTUAL)
- **Last updated:** 2025-05-11


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04734197

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04734197, "A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT04734197. Licensed CC0.

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