# Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma

> **NCT04749108** · PHASE2,PHASE3 · RECRUITING · sponsor: **Institut du Cancer de Montpellier - Val d'Aurelle** · enrollment: 1075 (estimated)

## Conditions studied

- Locally Advanced Malignant Neoplasm
- Rectal Carcinoma

## Interventions

- **DRUG:** Induction chemotherapy - modified FOLFIRINOX regimen
- **OTHER:** Early tumor response evaluation by MRI volumetry
- **RADIATION:** Radiochemotherapy Cap 50
- **PROCEDURE:** Radical proctectomy with total mesorectal excision

## Key facts

- **NCT ID:** NCT04749108
- **Lead sponsor:** Institut du Cancer de Montpellier - Val d'Aurelle
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-11-26
- **Primary completion:** 2026-08
- **Final completion:** 2026-08
- **Target enrollment:** 1075 (ESTIMATED)
- **Last updated:** 2026-02-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04749108

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04749108, "Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT04749108. Licensed CC0.

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