# A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children

> **NCT04750902** · PHASE2 · COMPLETED · sponsor: **Colgate Palmolive** · enrollment: 2000 (actual)

## Conditions studied

- Dental Caries

## Interventions

- **DRUG:** 0.24% Sodium Fluoride Dentifrice
- **DRUG:** 1.5% Arginine Dentifrice
- **DRUG:** 4.0% Arginine Dentifrice
- **DRUG:** 8.0% Arginine Dentifrice

## Key facts

- **NCT ID:** NCT04750902
- **Lead sponsor:** Colgate Palmolive
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-01-21
- **Primary completion:** 2024-02-29
- **Final completion:** 2024-02-29
- **Target enrollment:** 2000 (ACTUAL)
- **Last updated:** 2024-05-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04750902

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04750902, "A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children". Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/clinical/NCT04750902. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*