# Neural Response to Inflammatory Challenge in Major Depressive Disorder

> **NCT04751331** · PHASE1,PHASE2 · RECRUITING · sponsor: **Laureate Institute for Brain Research, Inc.** · enrollment: 180 (estimated)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **BIOLOGICAL:** LPS
- **BIOLOGICAL:** Saline

## Key facts

- **NCT ID:** NCT04751331
- **Lead sponsor:** Laureate Institute for Brain Research, Inc.
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-05-15
- **Primary completion:** 2026-04
- **Final completion:** 2026-12
- **Target enrollment:** 180 (ESTIMATED)
- **Last updated:** 2026-04-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04751331

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04751331, "Neural Response to Inflammatory Challenge in Major Depressive Disorder". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT04751331. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*