# Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes

> **NCT04754581** · NA · ACTIVE_NOT_RECRUITING · sponsor: **AdventHealth Translational Research Institute** · enrollment: 39 (actual)

## Conditions studied

- Type 2 Diabetes

## Interventions

- **OTHER:** Maximal ATP Production (ATPmax)
- **OTHER:** Exercise Testing (VO2max)
- **PROCEDURE:** Muscle Biopsy
- **PROCEDURE:** Adipose Tissue Biopsy
- **OTHER:** Hyperinsulinemic euglycemic clamp
- **OTHER:** PET imaging

## Key facts

- **NCT ID:** NCT04754581
- **Lead sponsor:** AdventHealth Translational Research Institute
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-03-30
- **Primary completion:** 2025-08-15
- **Final completion:** 2026-12
- **Target enrollment:** 39 (ACTUAL)
- **Last updated:** 2026-03-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04754581

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04754581, "Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04754581. Licensed CC0.

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