# Incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) Development in Participants With Neurofibromatosis Type 1 (NF1) Receiving and Not Receiving Medical Therapies Directed at Plexiform Neurofibromas (PN)

> **NCT04774289** · — · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 296 (actual)

## Conditions studied

- Neurofibromatosis 1
- Peripheral Nerve Neoplasms, Malignant

## Interventions

_None listed._

## Key facts

- **NCT ID:** NCT04774289
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2021-02-24
- **Primary completion:** 2022-03-01
- **Final completion:** 2022-12-08
- **Target enrollment:** 296 (ACTUAL)
- **Last updated:** 2024-09-19


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04774289

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04774289, "Incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) Development in Participants With Neurofibromatosis Type 1 (NF1) Receiving and Not Receiving Medical Therapies Directed at Plexiform Neurofibromas (PN)". Retrieved via AI Analytics 2026-08-11 from https://api.ai-analytics.org/clinical/NCT04774289. Licensed CC0.

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